5HRN
HIV Integrase Catalytic Domain containing F185K mutation complexed with GSK0002
Summary for 5HRN
Entry DOI | 10.2210/pdb5hrn/pdb |
Related | 5HOT 5HRP 5HRR 5HRS |
Descriptor | Integrase, CACODYLATE ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | viral dna integration, dna binding, ledgf binding, viral protein, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Human immunodeficiency virus 1 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 |
Total number of polymer chains | 1 |
Total formula weight | 18968.28 |
Authors | Nolte, R.T. (deposition date: 2016-01-23, release date: 2016-12-14, Last modification date: 2024-03-06) |
Primary citation | Gupta, K.,Turkki, V.,Sherrill-Mix, S.,Hwang, Y.,Eilers, G.,Taylor, L.,McDanal, C.,Wang, P.,Temelkoff, D.,Nolte, R.T.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.D.,Bushman, F.D. Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14:e1002584-e1002584, 2016 Cited by PubMed: 27935939DOI: 10.1371/journal.pbio.1002584 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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