5HQY

human dihydrofolate reductase complex with NADPH and 5-methyl-6-(2',3',4'-trifluorophenylthio)thieno[2,3-d]pyrimidine-2,4-diamine

Summary for 5HQY

• Entry DOI: 10.2210/pdb5hqy/pdb
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-methyl-6-[(2,3,4-trifluorophenyl)sulfanyl]thieno[2,3-d]pyrimidine-2,4-diamine, ... (4 entities in total)
• Functional Keywords: oxidoreductase ternary complex with trifluoromethyl inhibitor, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 22779.67

Authors

Cody, V. (deposition date: 2016-01-22, release date: 2017-01-25, Last modification date: 2023-09-27)

• Primary citation: Cody, V.,Gangjee, A.; Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.46 Å)