5HQ3

Stable, high-expression variant of human acetylcholinesterase

5HQ3 の概要

• エントリーDOI: 10.2210/pdb5hq3/pdb
• 分子名称: Acetylcholinesterase, O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
• 機能のキーワード: design, de novo protein, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell junction, synapse . Isoform T: Nucleus. Isoform H: Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side : P22303 P22303
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 123155.34

構造登録者

Goldenzweig, A.,Goldsmith, M.,Hill, S.E.,Gertman, O.,Laurino, P.,Ashani, Y.,Dym, O.,Albeck, S.,Unger, T.,Prilusky, J.,Lieberman, R.L.,Aharoni, A.,Silman, I.,Sussman, J.L.,Tawfik, D.S.,Fleishman, S.J. (登録日: 2016-01-21, 公開日: 2016-07-27, 最終更新日: 2024-01-10)

• 主引用文献: Goldenzweig, A.,Goldsmith, M.,Hill, S.E.,Gertman, O.,Laurino, P.,Ashani, Y.,Dym, O.,Unger, T.,Albeck, S.,Prilusky, J.,Lieberman, R.L.,Aharoni, A.,Silman, I.,Sussman, J.L.,Tawfik, D.S.,Fleishman, S.J.; Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.; Mol.Cell, 63:337-346, 2016; PubMed: 27425410; DOI: 10.1016/j.molcel.2016.06.012

実験手法

X-RAY DIFFRACTION (2.6 Å)