5HPB
human dihydrofolate reductase complex with NADPH and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine
Summary for 5HPB
Entry DOI | 10.2210/pdb5hpb/pdb |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-methyl-6-{[4-(trifluoromethyl)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine, ... (5 entities in total) |
Functional Keywords | oxidoreductase ternary complex with trifluoromethyl inhibitor, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 22643.46 |
Authors | Cody, V.,Ganjee, A. (deposition date: 2016-01-20, release date: 2017-01-25, Last modification date: 2023-09-27) |
Primary citation | Cody, V.,Gangjee, A. Human dihydrofolate reductase ternary complex with a series offluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report