5HNS

Structure of glycosylated NPC1 luminal domain C

Summary for 5HNS

Entry DOI	10.2210/pdb5hns/pdb
Descriptor	Niemann-Pick C1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	niemann-pick disease type c, npc1, npc2, cholesterol transport, ebola virus receptor, ebola virus susceptibility, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	60725.66
Authors	Zhao, Y.,Ren, J.,Harlos, K.,Stuart, D.I. (deposition date: 2016-01-18, release date: 2016-02-10, Last modification date: 2020-07-29)
Primary citation	Zhao, Y.,Ren, J.,Harlos, K.,Stuart, D.I. Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions. Febs Lett., 590:605-612, 2016 Cited by PubMed: 26846330 DOI: 10.1002/1873-3468.12089 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation