5HMH

HDM2 in complex with a 3,3-Disubstituted Piperidine

5HMH の概要

• エントリーDOI: 10.2210/pdb5hmh/pdb
• 関連するPDBエントリー: 5HMI 5HMK
• 分子名称: E3 ubiquitin-protein ligase Mdm2, 4-[2-(4-{[(2R,3S)-2-propyl-1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}-3-{[5-(trifluoromethyl)thiophen-3-yl]oxy}piperidin-3-yl]carbonyl}piperazin-1-yl)phenoxy]butanoic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: oncology, e3 ubiquitin-protein ligase, p53/tp53, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus, nucleoplasm: Q00987
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24772.34

構造登録者

Scapin, G. (登録日: 2016-01-16, 公開日: 2016-04-06, 最終更新日: 2024-03-06)

• 主引用文献: Bogen, S.L.,Pan, W.,Gibeau, C.R.,Lahue, B.R.,Ma, Y.,Nair, L.G.,Seigel, E.,Shipps, G.W.,Tian, Y.,Wang, Y.,Lin, Y.,Liu, M.,Liu, S.,Mirza, A.,Wang, X.,Lipari, P.,Seidel-Dugan, C.,Hicklin, D.J.,Bishop, W.R.,Rindgen, D.,Nomeir, A.,Prosise, W.,Reichert, P.,Scapin, G.,Strickland, C.,Doll, R.J.; Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.; Acs Med.Chem.Lett., 7:324-329, 2016; PubMed: 26985323; DOI: 10.1021/acsmedchemlett.5b00472

実験手法

X-RAY DIFFRACTION (1.79 Å)