5HKL

Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with inorganic phosphate

5HKL の概要

• エントリーDOI: 10.2210/pdb5hkl/pdb
• 分子名称: Orotate phosphoribosyltransferase, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: oprt, de novo pyrimidine nucleotide synthesis, inorganic phosphate complex, transferase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40776.92

構造登録者

Donini, S.,Bolognesi, G.,Rizzi, M. (登録日: 2016-01-14, 公開日: 2017-01-25, 最終更新日: 2024-01-10)

• 主引用文献: Donini, S.,Ferraris, D.M.,Miggiano, R.,Massarotti, A.,Rizzi, M.; Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.; Sci Rep, 7:1180-1180, 2017; PubMed: 28446777; DOI: 10.1038/s41598-017-01057-z

実験手法

X-RAY DIFFRACTION (1.899 Å)