5HKA

Crystal structure of the CFTR inhibitory factor Cif bound to an amide inhibitor

5HKA の概要

• エントリーDOI: 10.2210/pdb5hka/pdb
• 関連するPDBエントリー: 3KD2 4YX9 5HK9 5HKB
• 分子名称: CFTR inhibitory factor, 5'-[2,6-dichloro-4-(propanoylamino)phenoxy]-2'-hydroxybiphenyl-4-carboxamide (3 entities in total)
• 機能のキーワード: bacterial epoxide hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Pseudomonas aeruginosa (strain UCBPP-PA14)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 138439.98

構造登録者

Hvorecny, K.L.,Madden, D.R. (登録日: 2016-01-13, 公開日: 2016-05-18, 最終更新日: 2023-09-27)

• 主引用文献: Kitamura, S.,Hvorecny, K.L.,Niu, J.,Hammock, B.D.,Madden, D.R.,Morisseau, C.; Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa.; J.Med.Chem., 59:4790-4799, 2016; PubMed: 27120257; DOI: 10.1021/acs.jmedchem.6b00173

実験手法

X-RAY DIFFRACTION (2.05 Å)