4YX9

Crystal structure of the CFTR inhibitory factor Cif bound to tiratricol

Summary for 4YX9

• Entry DOI: 10.2210/pdb4yx9/pdb
• Related: 3KD2
• Descriptor: CFTR inhibitory factor, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID (3 entities in total)
• Functional Keywords: inhibitor, enzyme, cif, cftr, epoxide hydrolase, alpha beta hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Pseudomonas aeruginosa (strain UCBPP-PA14)
• Total number of polymer chains: 4
• Total formula weight: 139146.52

Authors

Bahl, C.D.,Madden, D.R. (deposition date: 2015-03-22, release date: 2015-07-15, Last modification date: 2023-09-27)

• Primary citation: Bahl, C.D.,Hvorecny, K.L.,Bomberger, J.M.,Stanton, B.A.,Hammock, B.D.,Morisseau, C.,Madden, D.R.; Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR.; Angew.Chem.Int.Ed.Engl., 54:9881-9885, 2015; PubMed: 26136396; DOI: 10.1002/anie.201503983

Experimental method

X-RAY DIFFRACTION (1.75 Å)