5HIM
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylhomocysteine and dimethylglycine
Summary for 5HIM
Entry DOI | 10.2210/pdb5him/pdb |
Related | 5GWX 5H02 5HII 5HIJ 5HIK 5HIL |
Descriptor | Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, N,N-DIMETHYLGLYCINE, ... (5 entities in total) |
Functional Keywords | s-adenosylmethionine-dependent methyltransferases (sam or adomet-mtase), class i, monomethylation of glycine and sarcosine, rate-limiting enzyme in betaine biosynthesis, betaine-mediated feedback inhibition, transferase |
Biological source | Methanohalophilus portucalensis FDF-1 |
Total number of polymer chains | 1 |
Total formula weight | 33660.23 |
Authors | |
Primary citation | Lee, Y.R.,Lin, T.S.,Lai, S.J.,Liu, M.S.,Lai, M.C.,Chan, N.L. Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity Sci Rep, 6:38071-38071, 2016 Cited by PubMed: 27934872DOI: 10.1038/srep38071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.338 Å) |
Structure validation
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