5HIA

Human hypoxanthine-guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine

5HIA の概要

• エントリーDOI: 10.2210/pdb5hia/pdb
• 関連するPDBエントリー: 5HIG
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-y l]-3-oxidanylidene-propyl]phosphonic acid, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: purine salvage, malaria, nuceloside phosphonate, enzyme, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P00492
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 103688.34

構造登録者

Guddat, L.W.,Keough, D.T.,Rejman, D. (登録日: 2016-01-11, 公開日: 2017-01-18, 最終更新日: 2023-09-27)

• 主引用文献: Keough, D.T.,Rejman, D.,Pohl, R.,Zbornikova, E.,Hockova, D.,Croll, T.,Edstein, M.D.,Birrell, G.W.,Chavchich, M.,Naesens, L.M.J.,Pierens, G.K.,Brereton, I.M.,Guddat, L.W.; Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.; ACS Chem. Biol., 2017; PubMed: 29161011; DOI: 10.1021/acschembio.7b00916

実験手法

X-RAY DIFFRACTION (1.773 Å)