5HHW

Crystal structure of insulin receptor kinase domain in complex with cis-(R)-7-(3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-((tetrahydro-2H-pyran-2-yl)methoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine.

Summary for 5HHW

Entry DOI	10.2210/pdb5hhw/pdb
Descriptor	Insulin receptor, 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{R})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	inhibitor, complex, insulin receptor, kinase, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein: P06213
Total number of polymer chains	1
Total formula weight	35448.66
Authors	Scheufler, C.,Izaac, A.,Stauffer, F. (deposition date: 2016-01-11, release date: 2016-04-13, Last modification date: 2018-01-24)
Primary citation	Stauffer, F.,Cowan-Jacob, S.W.,Scheufler, C.,Furet, P. Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors. Bioorg.Med.Chem.Lett., 26:2065-2067, 2016 Cited by PubMed: 26951750 DOI: 10.1016/j.bmcl.2016.02.074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation