5HHD

Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21

Summary for 5HHD

• Entry DOI: 10.2210/pdb5hhd/pdb
• Related: 4GLS
• Descriptor: Vascular endothelial growth factor A, D-Peptide RFX037.D, D-Vascular endothelial growth factor, ... (7 entities in total)
• Functional Keywords: heterochiral protein-protein complex, d-protein antagonist, growth factor-inhibitor complex, racemic crystallography, de novo protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 79497.07

Authors

Uppalapati, M.,LEE, D.J.,Mandal, K.,Kent, S.B.H.,Sidhu, S. (deposition date: 2016-01-10, release date: 2016-03-09, Last modification date: 2023-11-15)

• Primary citation: Uppalapati, M.,Lee, D.J.,Mandal, K.,Li, H.,Miranda, L.P.,Lowitz, J.,Kenney, J.,Adams, J.J.,Ault-Riche, D.,Kent, S.B.,Sidhu, S.S.; A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.; Acs Chem.Biol., 11:1058-1065, 2016; PubMed: 26745345; DOI: 10.1021/acschembio.5b01006

Experimental method

X-RAY DIFFRACTION (2.1 Å)