5HH5
Crystal structure of B3 metallo-beta-lactamase L1 complexed with a phosphonate-based inhibitor
Summary for 5HH5
Entry DOI | 10.2210/pdb5hh5/pdb |
Descriptor | Metallo-beta-lactamase L1, ZINC ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | inhibitor, carbapenamase, pyridine, phosphonate, antibiotic resistance, hydrolase |
Biological source | Stenotrophomonas maltophilia (Pseudomonas maltophilia) |
Total number of polymer chains | 1 |
Total formula weight | 29653.49 |
Authors | Hinchliffe, P.,Spencer, J. (deposition date: 2016-01-09, release date: 2017-01-18, Last modification date: 2024-01-10) |
Primary citation | Hinchliffe, P.,Tanner, C.A.,Krismanich, A.P.,Labbe, G.,Goodfellow, V.J.,Marrone, L.,Desoky, A.Y.,Calvopina, K.,Whittle, E.E.,Zeng, F.,Avison, M.B.,Bols, N.C.,Siemann, S.,Spencer, J.,Dmitrienko, G.I. Structural and Kinetic Studies of the Potent Inhibition of Metallo-beta-lactamases by 6-Phosphonomethylpyridine-2-carboxylates. Biochemistry, 57:1880-1892, 2018 Cited by PubMed: 29485857DOI: 10.1021/acs.biochem.7b01299 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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