5HH3

OxyA from Actinoplanes teichomyceticus

5HH3 の概要

• エントリーDOI: 10.2210/pdb5hh3/pdb
• 分子名称: OxyA protein, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: cytochrome p450 monooxygenase, phenolic coupling enzyme, biosynthesis of glycopeptide antibiotics, peptide cyclase, oxidoreductase
• 由来する生物種: Actinoplanes teichomyceticus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 91189.51

構造登録者

Haslinger, K.,Cryle, M.J. (登録日: 2016-01-09, 公開日: 2016-02-10, 最終更新日: 2024-01-10)

主引用文献

Haslinger, K.,Cryle, M.J.
Structure of OxyAtei : completing our picture of the glycopeptide antibiotic producing Cytochrome P450 cascade.
Febs Lett., 590:571-581, 2016

PubMed Abstract: Cyclization of glycopeptide antibiotic precursors occurs in either three or four steps catalyzed by Cytochrome P450 enzymes. Three of these enzymes have been structurally characterized to date with the second enzyme along the pathway, OxyA, escaping structural analysis. We are now able to present the structure of OxyAtei involved in teicoplanin biosynthesis - the same enzyme recently shown to be the first active OxyA homolog. In spite of the hydrophobic character of the teicoplanin precursor, the polar active site of OxyAtei and its affinity for certain azole inhibitors hint at its preference for substrates with polar decorations.

PubMed: 26820384
DOI: 10.1002/1873-3468.12081

実験手法

X-RAY DIFFRACTION (2.1 Å)