5HGI

Crystal structure of apo human IRE1 alpha

Summary for 5HGI

Entry DOI	10.2210/pdb5hgi/pdb
Descriptor	Serine/threonine-protein kinase/endoribonuclease IRE1, CESIUM ION, SODIUM ION, ... (8 entities in total)
Functional Keywords	ser/thr protein kinase, rnase, transferase-oxidoreductase complex, transferase/oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane ; Single-pass type I membrane protein : O75460
Total number of polymer chains	1
Total formula weight	50620.56
Authors	Feldman, H.C.,Tong, M.,Wang, L.,Meza-Acevedo, R.,Gobillot, T.A.,Gliedt, J.M.,Hari, S.B.,Mitra, A.K.,Backes, B.J.,Papa, F.R.,Seeliger, M.A.,Maly, D.J. (deposition date: 2016-01-08, release date: 2016-06-08, Last modification date: 2023-09-27)
Primary citation	Feldman, H.C.,Tong, M.,Wang, L.,Meza-Acevedo, R.,Gobillot, T.A.,Lebedev, I.,Gliedt, M.J.,Hari, S.B.,Mitra, A.K.,Backes, B.J.,Papa, F.R.,Seeliger, M.A.,Maly, D.J. Structural and Functional Analysis of the Allosteric Inhibition of IRE1 alpha with ATP-Competitive Ligands. Acs Chem.Biol., 11:2195-2205, 2016 Cited by PubMed: 27227314 DOI: 10.1021/acschembio.5b00940 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.584 Å)

Structure validation