5HF2

Staphylococcus aureus Dihydrofolate Reductase complexed with cyclized alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1175)

5HF2 の概要

• エントリーDOI: 10.2210/pdb5hf2/pdb
• 関連するPDBエントリー: 4XEC 5HF0
• 分子名称: Dihydrofolate reductase, Tricyclic NADPH, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, nadph, propargyl-linked antifolates, dihydrofolate reductase, antibiotics
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19255.52

構造登録者

Reeve, S.M.,Anderson, A.C. (登録日: 2016-01-06, 公開日: 2017-01-18, 最終更新日: 2024-03-06)

• 主引用文献: Reeve, S.M.,Anderson, A.C.; Staphylococcus aureus Dihydrofolate Reductase complexed with cyclized alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1175); To Be Published,

実験手法

X-RAY DIFFRACTION (1.81 Å)