5HF0
Staphylococcus aureus Dihydrofolate Reductase complexed with beta-NADPH, cyclic alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106)
Summary for 5HF0
Entry DOI | 10.2210/pdb5hf0/pdb |
Related | 4XEC 5HF2 |
Descriptor | Dihydrofolate reductase, GLYCEROL, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid, ... (6 entities in total) |
Functional Keywords | oxidoreductase, dihydrofolate reductase, nadph, zwitterion, antibiotics |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 20379.34 |
Authors | Anderson, A.C.,Reeve, S.M. (deposition date: 2016-01-06, release date: 2017-01-18, Last modification date: 2024-03-06) |
Primary citation | Anderson, A.C.,Reeve, S.M. Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1106) To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.245 Å) |
Structure validation
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