5HEZ

JAK2 kinase (JH1 domain) mutant P1057A in complex with TG101209

Summary for 5HEZ

Entry DOI	10.2210/pdb5hez/pdb
Related	4JI9
Descriptor	Tyrosine-protein kinase JAK2, CHLORIDE ION, ZINC ION, ... (5 entities in total)
Functional Keywords	protein kinase, inhibitor, mutation, tyk2, surrogate, p1104a, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Endomembrane system ; Peripheral membrane protein : O60674
Total number of polymer chains	4
Total formula weight	146155.39
Authors	Ultsch, M.,Eigenbrot, C. (deposition date: 2016-01-06, release date: 2016-11-09, Last modification date: 2023-11-15)
Primary citation	Dendrou, C.A.,Cortes, A.,Shipman, L.,Evans, H.G.,Attfield, K.E.,Jostins, L.,Barber, T.,Kaur, G.,Kuttikkatte, S.B.,Leach, O.A.,Desel, C.,Faergeman, S.L.,Cheeseman, J.,Neville, M.J.,Sawcer, S.,Compston, A.,Johnson, A.R.,Everett, C.,Bell, J.I.,Karpe, F.,Ultsch, M.,Eigenbrot, C.,McVean, G.,Fugger, L. Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Sci Transl Med, 8:363ra149-363ra149, 2016 Cited by PubMed: 27807284 DOI: 10.1126/scitranslmed.aag1974 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.66 Å)

Structure validation