5HEZ
JAK2 kinase (JH1 domain) mutant P1057A in complex with TG101209
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tyrosine-protein kinase JAK2 | polymer | 302 | 35460.2 | 4 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | E, I, O (A, B, D) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 3 | F, L (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | G, H, J, K, M... (A, B, C, D) | N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | non-polymer | 509.7 | 8 | Chemie (1M3) | |||
| 5 | R, S, T, U (A, B, C, D) | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 833 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Gly 831 | - | expression tag |
| Ser 832 | - | expression tag |
| Ala 1057 | Pro 1057 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 141840.9 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 4314.5 | |
| All* | Total formula weight | 146155.4 |
