5HEZ

JAK2 kinase (JH1 domain) mutant P1057A in complex with TG101209

5HEZ の概要

• エントリーDOI: 10.2210/pdb5hez/pdb
• 関連するPDBエントリー: 4JI9
• 分子名称: Tyrosine-protein kinase JAK2, CHLORIDE ION, ZINC ION, ... (5 entities in total)
• 機能のキーワード: protein kinase, inhibitor, mutation, tyk2, surrogate, p1104a, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endomembrane system ; Peripheral membrane protein : O60674
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 146155.39

構造登録者

Ultsch, M.,Eigenbrot, C. (登録日: 2016-01-06, 公開日: 2016-11-09, 最終更新日: 2023-11-15)

• 主引用文献: Dendrou, C.A.,Cortes, A.,Shipman, L.,Evans, H.G.,Attfield, K.E.,Jostins, L.,Barber, T.,Kaur, G.,Kuttikkatte, S.B.,Leach, O.A.,Desel, C.,Faergeman, S.L.,Cheeseman, J.,Neville, M.J.,Sawcer, S.,Compston, A.,Johnson, A.R.,Everett, C.,Bell, J.I.,Karpe, F.,Ultsch, M.,Eigenbrot, C.,McVean, G.,Fugger, L.; Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.; Sci Transl Med, 8:363ra149-363ra149, 2016; PubMed: 27807284; DOI: 10.1126/scitranslmed.aag1974

実験手法

X-RAY DIFFRACTION (2.66 Å)