5HE1

Human GRK2 in complex with Gbetagamma subunits and CCG224062

5HE1 の概要

• エントリーDOI: 10.2210/pdb5he1/pdb
• 関連するPDBエントリー: 5HE0 5HE2 5HE3
• 分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: rgs, kinase, ph, wd-40, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 120494.58

構造登録者

Cato, M.C.,Tesmer, J.J.G. (登録日: 2016-01-05, 公開日: 2016-05-11, 最終更新日: 2024-03-06)

• 主引用文献: Waldschmidt, H.V.,Homan, K.T.,Cruz-Rodriguez, O.,Cato, M.C.,Waninger-Saroni, J.,Larimore, K.M.,Cannavo, A.,Song, J.,Cheung, J.Y.,Kirchhoff, P.D.,Koch, W.J.,Tesmer, J.J.,Larsen, S.D.; Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.; J.Med.Chem., 59:3793-3807, 2016; PubMed: 27050625; DOI: 10.1021/acs.jmedchem.5b02000

実験手法

X-RAY DIFFRACTION (3.15 Å)