5HD7
Dissecting Therapeutic Resistance to ERK Inhibition Rat Mutant SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide
Summary for 5HD7
Entry DOI | 10.2210/pdb5hd7/pdb |
Related | 5HD4 |
Descriptor | Mitogen-activated protein kinase 1, (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | transferase, serine/threonine-protein kinase, map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P63086 |
Total number of polymer chains | 1 |
Total formula weight | 43356.54 |
Authors | Jha, S.,Morris, E.J.,Hruza, A.,Mansueto, M.S.,Schroeder, G.,Arbanas, J.,McMasters, D.,Restaino, C.R.,Dayananth, R.,Black, S.,Elsen, N.L.,Mannarino, A.,Cooper, A.,Fawell, S.,Zawel, L.,Jayaraman, L.,Samatar, A.A. (deposition date: 2016-01-04, release date: 2016-02-24, Last modification date: 2024-03-06) |
Primary citation | Jha, S.,Morris, E.J.,Hruza, A.,Mansueto, M.S.,Schroeder, G.K.,Arbanas, J.,McMasters, D.,Restaino, C.R.,Dayananth, P.,Black, S.,Elsen, N.L.,Mannarino, A.,Cooper, A.,Fawell, S.,Zawel, L.,Jayaraman, L.,Samatar, A.A. Dissecting Therapeutic Resistance to ERK Inhibition. Mol.Cancer Ther., 15:548-559, 2016 Cited by PubMed: 26832798DOI: 10.1158/1535-7163.MCT-15-0172 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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