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5HD7

Dissecting Therapeutic Resistance to ERK Inhibition Rat Mutant SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Mitogen-activated protein kinase 1polymer36542288.51UniProt (P63086)
Pfam (PF00069)
Rattus norvegicus (Rat)MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2
2B
(A)
(3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamidenon-polymer587.71Chemie (38Z)
3C, D, E, F, G
(A)
SULFATE IONnon-polymer96.15Chemie (SO4)
4H
(A)
waterwater18.0274Chemie (HOH)
Sequence modifications
A: 1 - 358 (UniProt: P63086)
PDBExternal DatabaseDetails
Ala -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
His -2-expression tag
His -1-expression tag
His 0-expression tag
Asp 167Gly 167engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight42288.5
Non-Polymers*Number of molecules6
Total formula weight1068.0
All*Total formula weight43356.5
*Water molecules are not included.

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PDB entries from 2024-11-20

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