5HBM

Crystal Structure of a Dihydroxycoumarin RNase H Active-Site Inhibitor in Complex with HIV-1 Reverse Transcriptase

Summary for 5HBM

• Entry DOI: 10.2210/pdb5hbm/pdb
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, ... (6 entities in total)
• Functional Keywords: transferase, hydrolase, inhibitor, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Human immunodeficiency virus type 1 BH10 (HIV-1); More
• Total number of polymer chains: 2
• Total formula weight: 114698.13

Authors

Kirby, K.A.,Sarafianos, S.G. (deposition date: 2015-12-31, release date: 2016-02-24, Last modification date: 2023-09-27)

• Primary citation: Kirby, K.A.,Sarafianos, S.G.; Crystal Structure of a Dihydroxycoumarin RNase H Active-Site Inhibitor in Complex with HIV-1 Reverse Transcriptase; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.043 Å)