5HA7
Human Aldose Reductase in Complex with NADP+ and WY14643 in Space Group P212121
Summary for 5HA7
Entry DOI | 10.2210/pdb5ha7/pdb |
Related | 3Q65 |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID, ... (5 entities in total) |
Functional Keywords | alpha/beta barrel, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 2 |
Total formula weight | 74699.59 |
Authors | Sawaya, M.R.,Cascio, D.,Balendiran, G.K. (deposition date: 2015-12-30, release date: 2016-09-28, Last modification date: 2023-09-27) |
Primary citation | Sawaya, M.R.,Verma, M.,Balendiran, V.,Rath, N.P.,Cascio, D.,Balendiran, G.K. Characterization of WY 14,643 and its Complex with Aldose Reductase. Sci Rep, 6:34394-34394, 2016 Cited by PubMed: 27721416DOI: 10.1038/srep34394 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report