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5H8Q

Structure of the human GluN1/GluN2A LBD in complex with GNE8324

Summary for 5H8Q
Entry DOI10.2210/pdb5h8q/pdb
Related5H8F 5H8H 5H8N 5H8R 5H8S
DescriptorGlutamate receptor ionotropic, NMDA 2A,Glutamate receptor ionotropic, NMDA 2A, Glutamate receptor ionotropic, NMDA 1,Glutamate receptor ionotropic, NMDA 1, ACETATE ION, ... (7 entities in total)
Functional Keywordsglun1, glun2a, nmda, receptor, transport protein
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane ; Multi-pass membrane protein : Q12879 Q05586
Total number of polymer chains2
Total formula weight65917.17
Authors
Wallweber, H.J.A.,Lupardus, P.J. (deposition date: 2015-12-23, release date: 2016-02-24, Last modification date: 2023-09-27)
Primary citationHackos, D.H.,Lupardus, P.J.,Grand, T.,Chen, Y.,Wang, T.M.,Reynen, P.,Gustafson, A.,Wallweber, H.J.,Volgraf, M.,Sellers, B.D.,Schwarz, J.B.,Paoletti, P.,Sheng, M.,Zhou, Q.,Hanson, J.E.
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Neuron, 89:983-999, 2016
Cited by
PubMed: 26875626
DOI: 10.1016/j.neuron.2016.01.016
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

건을2024-03-27부터공개중

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