5H7E

Crystal Structure of native drCPDase

Summary for 5H7E

Entry DOI	10.2210/pdb5h7e/pdb
Related	5H7F
Descriptor	RNA 2',3'-cyclic phosphodiesterase, GLYCEROL, SULFATE ION, ... (4 entities in total)
Functional Keywords	rna repair, cpdase, 2, 3 -cyclic phosphodiesterase, hydrolase
Biological source	Deinococcus radiodurans
Total number of polymer chains	1
Total formula weight	21117.96
Authors	Han, W.,Hua, Y.,Zhao, Y. (deposition date: 2016-11-18, release date: 2017-09-27, Last modification date: 2023-11-08)
Primary citation	Han, W.,Cheng, J.,Zhou, C.,Hua, Y.,Zhao, Y. Crystal structure of the RNA 2',3'-cyclic phosphodiesterase from Deinococcus radiodurans Acta Crystallogr F Struct Biol Commun, 73:276-280, 2017 Cited by PubMed Abstract: 2',3'-Cyclic phosphodiesterase (CPDase) homologues have been found in all domains of life and are involved in diverse RNA and nucleotide metabolisms. The CPDase from Deinococcus radiodurans was crystallized and the crystals diffracted to 1.6 Å resolution, which is the highest resolution currently known for a CPDase structure. Structural comparisons revealed that the enzyme is in an open conformation in the absence of substrate. Nevertheless, the active site is well formed, and the representative motifs interact with sulfate ion, which suggests a conserved catalytic mechanism. PubMed: 28471359 DOI: 10.1107/S2053230X17004964 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation