5H3Q

Crystal Structure of TrkA kinase with ligand

5H3Q の概要

• エントリーDOI: 10.2210/pdb5h3q/pdb
• 分子名称: High affinity nerve growth factor receptor, 1-[(3S,4R)-4-[3,4-bis(fluoranyl)phenyl]-1-(2-methoxyethyl)pyrrolidin-3-yl]-3-(5-ethoxy-4-methyl-2-phenyl-pyrazol-3-yl)urea, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (5 entities in total)
• 機能のキーワード: trka inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37325.97

構造登録者

Noritaka, F. (登録日: 2016-10-26, 公開日: 2017-02-22, 最終更新日: 2023-11-08)

• 主引用文献: Furuya, N.,Momose, T.,Katsuno, K.,Fushimi, N.,Muranaka, H.,Handa, C.,Ozawa, T.,Kinoshita, T.; The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity; Bioorg. Med. Chem. Lett., 27:1233-1236, 2017; PubMed: 28159414; DOI: 10.1016/j.bmcl.2017.01.056

実験手法

X-RAY DIFFRACTION (2.1 Å)