5H22

Hsp90 alpha N-terminal domain in complex with an inhibitor

Summary for 5H22

Entry DOI	10.2210/pdb5h22/pdb
Descriptor	Hsp90aa1 protein, 4-chloranyl-7-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl]-5-(phenylmethyl)pyrrolo[2,3-d]pyrimidin-2-amine (3 entities in total)
Functional Keywords	hsp90, inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	24517.17
Authors	Kim, E.E.,Shin, S.C.,Keum, G.C. (deposition date: 2016-10-13, release date: 2017-10-11, Last modification date: 2023-11-08)
Primary citation	Lee, J.H.,Shin, S.C.,Seo, S.H.,Seo, Y.H.,Jeong, N.,Kim, C.W.,Kim, E.E.,Keum, G. Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. Bioorg. Med. Chem. Lett., 27:237-241, 2017 Cited by PubMed: 27914802 DOI: 10.1016/j.bmcl.2016.11.062 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.499 Å)

Structure validation