5H1D

Crystal structure of C-terminal of RhoGDI2

5H1D の概要

• エントリーDOI: 10.2210/pdb5h1d/pdb
• 分子名称: Rho GDP-dissociation inhibitor 2 (2 entities in total)
• 機能のキーワード: signaling protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytosol : P52566
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16427.71

構造登録者

Liu, J. (登録日: 2016-10-08, 公開日: 2016-10-26, 最終更新日: 2023-11-08)

主引用文献

Liu, J.,Gao, J.,Li, F.,Ma, R.,Wei, Q.,Wang, A.,Wu, J.,Ruan, K.
NMR characterization of weak interactions between RhoGDI2 and fragment screening hits.
Biochim. Biophys. Acta, 1861:3061-3070, 2017

PubMed Abstract: The delineation of intrinsically weak interactions between novel targets and fragment screening hits has long limited the pace of hit-to-lead evolution. Rho guanine-nucleotide dissociation inhibitor 2 (RhoGDI2) is a novel target that lacks any chemical probes for the treatment of tumor metastasis.

PubMed: 27721047
DOI: 10.1016/j.bbagen.2016.10.003

実験手法

X-RAY DIFFRACTION (1.494 Å)