5GWY

Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design

Summary for 5GWY

• Entry DOI: 10.2210/pdb5gwy/pdb
• Related PRD ID: PRD_002214
• Descriptor: main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
• Functional Keywords: hcov-nl63, main protease, inhibitor, complex, drug design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human coronavirus NL63 (HCoV-NL63); More
• Total number of polymer chains: 4
• Total formula weight: 67710.74

Authors

Wang, F.,Chen, C.,Tan, W.,Yang, K.,Yang, H. (deposition date: 2016-09-14, release date: 2017-09-20, Last modification date: 2023-11-15)

• Primary citation: Wang, F.,Chen, C.,Tan, W.,Yang, K.,Yang, H.; Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design.; Sci Rep, 6:22677-22677, 2016; PubMed: 26948040; DOI: 10.1038/srep22677

Experimental method

X-RAY DIFFRACTION (2.852 Å)