Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873R

Summary for 5GWI

Related5GWJ 5GWK
DescriptorDNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... (7 entities in total)
Functional Keywordstype ii topoisomerase, anti-cancer drug, topoii cleavage complex, isomerase-dna complex, isomerase-dna-isomerase inhibitor complex, isomerase/dna/isomerase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm Q02880
Total number of polymer chains6
Total molecular weight199302.65
Wang, Y.R.,Chen, S.F.,Wu, C.C.,Chan, N.L. (deposition date: 2016-09-12, release date: 2017-08-23, Last modification date: 2017-12-13)
Primary citation
Wang, Y.R.,Chen, S.F.,Wu, C.C.,Liao, Y.W.,Lin, T.S.,Liu, K.T.,Chen, Y.S.,Li, T.K.,Chien, T.C.,Chan, N.L.
Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45:10861-10871, 2017
PubMed: 28977631 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkx742
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2543003.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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