5GTC

Crystal structure of complex between DMAP-SH conjugated with a Kaposi's sarcoma herpesvirus LANA peptide (5-15) and nucleosome core particle

5GTC の概要

• エントリーDOI: 10.2210/pdb5gtc/pdb
• 分子名称: Histone H3.1, Histone H4, Histone H2A type 1-B/E, ... (8 entities in total)
• 機能のキーワード: dna binding, nucleus, histone fold, chromatin formation, nucleosome, structural protein-dna complex, structural protein/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: P68431 P62805 P04908 P06899
• タンパク質・核酸の鎖数: 11
• 化学式量合計: 203880.50

構造登録者

Arimura, Y.,Kato, D.,Suto, H.,Kurumizaka, H.,Kawashima, S.A.,Yamatsugu, K.,Kanai, M. (登録日: 2016-08-19, 公開日: 2017-06-28, 最終更新日: 2023-11-08)

• 主引用文献: Amamoto, Y.,Aoi, Y.,Nagashima, N.,Suto, H.,Yoshidome, D.,Arimura, Y.,Osakabe, A.,Kato, D.,Kurumizaka, H.,Kawashima, S.A.,Yamatsugu, K.,Kanai, M.; Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin.; J. Am. Chem. Soc., 139:7568-7576, 2017; PubMed: 28534629; DOI: 10.1021/jacs.7b02138

実験手法

X-RAY DIFFRACTION (2.7 Å)