5GP1

Crystal structure of ZIKV NS5 Methyltransferase in complex with GTP and SAH

Summary for 5GP1

• Entry DOI: 10.2210/pdb5gp1/pdb
• Related: 5GOZ
• Descriptor: RNA-directed RNA polymerase NS5, SULFATE ION, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: methyltransferase gtp complex, transferase
• Biological source: Zika virus (ZIKV)
• Total number of polymer chains: 3
• Total formula weight: 93478.48

Authors

Zhang, C.,Jin, T. (deposition date: 2016-07-30, release date: 2016-12-07, Last modification date: 2017-10-18)

• Primary citation: Zhang, C.,Feng, T.,Cheng, J.,Li, Y.,Yin, X.,Zeng, W.,Jin, X.,Li, Y.,Guo, F.,Jin, T.; Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design; Biochem. Biophys. Res. Commun., 492:624-630, 2017; PubMed: 27866982; DOI: 10.1016/j.bbrc.2016.11.098

Experimental method

X-RAY DIFFRACTION (2.444 Å)