5GMM

Crystal structure of human Carbonic anhydrase I in complex with polmacoxib

Summary for 5GMM

• Entry DOI: 10.2210/pdb5gmm/pdb
• Related: 5GMN
• Descriptor: Carbonic anhydrase 1, ZINC ION, 4-[3-(3-fluorophenyl)-5,5-dimethyl-4-oxidanylidene-furan-2-yl]benzenesulfonamide, ... (4 entities in total)
• Functional Keywords: lyase, inhibitor, complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 60176.92

Authors

Kim, H.T.,Hwang, K.Y. (deposition date: 2016-07-14, release date: 2017-05-24, Last modification date: 2023-11-08)

• Primary citation: Kim, H.T.,Cha, H.,Hwang, K.Y.; Structural insight into the inhibition of carbonic anhydrase by the COX-2-selective inhibitor polmacoxib (CG100649).; Biochem. Biophys. Res. Commun., 478:1-6, 2016; PubMed: 27475498; DOI: 10.1016/j.bbrc.2016.07.114

Experimental method

X-RAY DIFFRACTION (2.003 Å)