5G6V

Crystal structure of the PCTAIRE1 kinase in complex with inhibitor

5G6V の概要

• エントリーDOI: 10.2210/pdb5g6v/pdb
• 分子名称: CYCLIN-DEPENDENT KINASE 16, 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: Q00536
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75973.02

構造登録者

Dixon-Clarke, S.E.,Galan Bartual, S.,Elkins, J.,Savitsky, P.,Kopec, J.,Mackenzie, A.,Tallant, C.,Heroven, C.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (登録日: 2016-08-16, 公開日: 2016-11-23, 最終更新日: 2024-06-19)

• 主引用文献: Dixon-Clarke, S.E.,Shehata, S.N.,Krojer, T.,Sharpe, T.D.,von Delft, F.,Sakamoto, K.,Bullock, A.N.; Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.; Biochem.J., 474:699-713, 2017; PubMed: 28057719; DOI: 10.1042/BCJ20160941

実験手法

X-RAY DIFFRACTION (2.2 Å)