5G64

The complex between human IgE-Fc and two anti-IgE Fab fragments

5G64 の概要

• エントリーDOI: 10.2210/pdb5g64/pdb
• 分子名称: IG EPSILON CHAIN C REGION, FAB FRAGMENT, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: immune system, immunoglobulin e, omalizumab, ige-fc
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 171887.04

構造登録者

Davies, A.M.,Allan, E.G.,Keeble, A.H.,Delgado, J.,Cossins, B.P.,Mitropoulou, A.N.,Pang, M.O.Y.,Ceska, T.,Beavil, A.J.,Craggs, G.,Westwood, M.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J. (登録日: 2016-06-14, 公開日: 2017-05-03, 最終更新日: 2024-01-10)

• 主引用文献: Davies, A.M.,Allan, E.G.,Keeble, A.H.,Delgado, J.,Cossins, B.P.,Mitropoulou, A.N.,Pang, M.O.Y.,Ceska, T.,Beavil, A.J.,Craggs, G.,Westwood, M.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J.; Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.; J. Biol. Chem., 292:9975-9987, 2017; PubMed: 28438838; DOI: 10.1074/jbc.M117.776476

実験手法

X-RAY DIFFRACTION (3.715 Å)