5G55

3-Quinoline Carboxamides inhibitors of Pi3K

5G55 の概要

• エントリーDOI: 10.2210/pdb5g55/pdb
• 分子名称: PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 6-cyano-4-[[(1R)-1-(4-methylphenyl)ethyl]amino]quinoline-3-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: transferase, atm
• 由来する生物種: HOMO SAPIENS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111182.61

構造登録者

Edman, K.,Phillips, C. (登録日: 2016-05-20, 公開日: 2016-08-03, 最終更新日: 2024-05-08)

• 主引用文献: Degorce, S.L.,Barlaam, B.,Cadogan, E.,Dishington, A.P.,Ducray, R.,Glossop, S.C.,Hassall, L.A.,Lach, F.,Lau, A.,Mcguire, T.M.,Nowak, T.,Ouvry, G.,Pike, K.G.,Thomason, A.G.; Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (Atm) Kinase.; J.Med.Chem., 59:6281-, 2016; PubMed: 27259031; DOI: 10.1021/ACS.JMEDCHEM.6B00519

実験手法

X-RAY DIFFRACTION (2.45 Å)