5G4X

The crystal structure of the SHANK3 N-terminus

Summary for 5G4X

Entry DOI	10.2210/pdb5g4x/pdb
Descriptor	SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 3, 1,2-ETHANEDIOL (3 entities in total)
Functional Keywords	structural protein, shank3, ras, integrin.
Biological source	RATTUS NORVEGICUS (NORWAY RAT)
Cellular location	Cytoplasm: Q9JLU4
Total number of polymer chains	1
Total formula weight	40493.68
Authors	Zacharchenko, T.,Barsukov, I. (deposition date: 2016-05-17, release date: 2017-01-25, Last modification date: 2024-01-10)
Primary citation	Lilja, J.,Zacharchenko, T.,Georgiadou, M.,Jacquemet, G.,Franceschi, N.,Peuhu, E.,Hamidi, H.,Pouwels, J.,Martens, V.,Nia, F.H.,Beifuss, M.,Boeckers, T.,Kreienkamp, H.J.,Barsukov, I.L.,Ivaska, J. SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. Nat. Cell Biol., 19:292-305, 2017 Cited by PubMed: 28263956 DOI: 10.1038/ncb3487 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.166 Å)

Structure validation