5G3N
Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor.
Summary for 5G3N
Entry DOI | 10.2210/pdb5g3n/pdb |
Related | 5G3M |
Descriptor | PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED, CALCIUM ION, FORMIC ACID, ... (5 entities in total) |
Functional Keywords | hydrolase, spla2, secreted phospholipase a2, cardiovascular disease, inhibitor, fragment |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane ; Peripheral membrane protein : P14555 |
Total number of polymer chains | 2 |
Total formula weight | 29413.81 |
Authors | Sandmark, J.,Bodin, C.,Hallberg, K. (deposition date: 2016-04-29, release date: 2016-09-14, Last modification date: 2018-04-04) |
Primary citation | Giordanetto, F.,Pettersen, D.,Starke, I.,Nordberg, P.,Dahlstrom, M.,Knerr, L.,Selmi, N.,Rosengren, B.,Larsson, L.O.,Sandmark, J.,Castaldo, M.,Dekker, N.,Karlsson, U.,Hurt-Camejo, E. Discovery of Azd2716: A Novel Secreted Phospholipase A2 (Spla2) Inhibitor for the Treatment of Coronary Artery Disease Acs Med.Chem.Lett., 7:884-, 2016 Cited by PubMed: 27774123DOI: 10.1021/ACSMEDCHEMLETT.6B00188 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report