5G3N

Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor.

Summary for 5G3N

• Entry DOI: 10.2210/pdb5g3n/pdb
• Related: 5G3M
• Descriptor: PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED, CALCIUM ION, FORMIC ACID, ... (5 entities in total)
• Functional Keywords: hydrolase, spla2, secreted phospholipase a2, cardiovascular disease, inhibitor, fragment
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cell membrane ; Peripheral membrane protein : P14555
• Total number of polymer chains: 2
• Total formula weight: 29413.81

Authors

Sandmark, J.,Bodin, C.,Hallberg, K. (deposition date: 2016-04-29, release date: 2016-09-14, Last modification date: 2018-04-04)

• Primary citation: Giordanetto, F.,Pettersen, D.,Starke, I.,Nordberg, P.,Dahlstrom, M.,Knerr, L.,Selmi, N.,Rosengren, B.,Larsson, L.O.,Sandmark, J.,Castaldo, M.,Dekker, N.,Karlsson, U.,Hurt-Camejo, E.; Discovery of Azd2716: A Novel Secreted Phospholipase A2 (Spla2) Inhibitor for the Treatment of Coronary Artery Disease; Acs Med.Chem.Lett., 7:884-, 2016; PubMed: 27774123; DOI: 10.1021/ACSMEDCHEMLETT.6B00188

Experimental method

X-RAY DIFFRACTION (1.8 Å)