5G3N
Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED | polymer | 127 | 14221.3 | 2 | UniProt (P14555) Pfam (PF00068) | HOMO SAPIENS (HUMAN) | 3SECRETED PHOSPHOLIPASE A2 TYPE IIA, GIIC SPLA2, GROUP IIA PHOSPHOLIPASE A2, NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, NPS-PLA2, PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE 2A |
| 2 | C, D, G, H (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 3 | E, I (A, B) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 4 | F, J (A, B) | 3-(5'-BENZYL-2'-CARBAMOYLBIPHENYL-3-YL)PROPANOIC ACID | non-polymer | 359.4 | 2 | Chemie (X28) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 124 (UniProt: P14555)
| PDB | External Database | Details |
|---|---|---|
| Ala 1 | Asn 21 | engineered mutation |
| Ser 76 | Thr 96 | engineered mutation |
| Gly 125 | - | expression tag |
| His 126 | - | expression tag |
| His 127 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28442.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 971.2 | |
| All* | Total formula weight | 29413.8 |
