5G1Z

Plasmodium vivax N-myristoyltransferase in complex with a quinoline inhibitor (compound 1)

Summary for 5G1Z

Entry DOI	10.2210/pdb5g1z/pdb
Related	5G20 5G21 5G22
Descriptor	GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2-oxopentadecyl-CoA, ethyl 4-(2-cyanoethylsulfanyl)-6-methoxy-quinoline-3-carboxylate, ... (8 entities in total)
Functional Keywords	transferase, myristoylation, malaria, inhibitor, quinoline, drug design
Biological source	PLASMODIUM VIVAX (MALARIA PARASITE P. VIVAX)
Total number of polymer chains	3
Total formula weight	139787.48
Authors	Goncalves, V.,Brannigan, J.A.,Laporte, A.,Bell, A.S.,Roberts, S.M.,Wilkinson, A.J.,Leatherbarrow, R.J.,Tate, E.W. (deposition date: 2016-04-06, release date: 2017-02-15, Last modification date: 2024-05-08)
Primary citation	Goncalves, V.,Brannigan, J.A.,Laporte, A.,Bell, A.S.,Roberts, S.M.,Wilkinson, A.J.,Leatherbarrow, R.J.,Tate, E.W. Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase. Medchemcomm, 8:191-197, 2017 Cited by PubMed: 28626547 DOI: 10.1039/c6md00531d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation