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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5G1Z

Plasmodium vivax N-myristoyltransferase in complex with a quinoline inhibitor (compound 1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006499	biological_process	N-terminal protein myristoylation
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046872	molecular_function	metal ion binding
B	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006499	biological_process	N-terminal protein myristoylation
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046872	molecular_function	metal ion binding
C	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006499	biological_process	N-terminal protein myristoylation
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	39
Details	BINDING SITE FOR RESIDUE NHW A 1000

Chain	Residue
A	TYR28
A	LEU163
A	CYS164
A	VAL165
A	ARG170
A	SER171
A	LYS172
A	ARG173
A	LEU174
A	ALA175
A	PRO176
A	LYS29
A	THR183
A	ASN187
A	TRP192
A	GLN193
A	ALA194
A	TYR196
A	THR197
A	LEU202
A	TYR393
A	MG1412
A	PHE30
A	HOH2001
A	HOH2004
A	HOH2341
A	HOH2350
A	HOH2608
A	HOH2609
A	HOH2610
A	HOH2611
A	HOH2612
A	HOH2613
A	TRP31
A	ASN94
A	TYR95
A	VAL96
A	ASN161
A	PHE162

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE U53 A 1001

Chain	Residue
A	VAL96
A	GLU97
A	ASP98
A	PHE103
A	PHE105
A	TYR211
A	HIS213
A	PHE226
A	SER319
A	TYR334
A	ASN365
A	HOH2542
A	HOH2593

site_id	AC3
Number of Residues	40
Details	BINDING SITE FOR RESIDUE NHW B 1000

Chain	Residue
B	TYR28
B	LYS29
B	PHE30
B	TRP31
B	ASN94
B	TYR95
B	VAL96
B	ASN161
B	PHE162
B	LEU163
B	CYS164
B	VAL165
B	ARG170
B	SER171
B	LYS172
B	ARG173
B	LEU174
B	ALA175
B	PRO176
B	THR183
B	ILE186
B	TRP192
B	GLN193
B	ALA194
B	TYR196
B	THR197
B	LEU202
B	TYR393
B	MG1412
B	HOH2002
B	HOH2003
B	HOH2266
B	HOH2272
B	HOH2273
B	HOH2500
B	HOH2501
B	HOH2502
B	HOH2503
B	HOH2504
B	HOH2505

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE U53 B 1001

Chain	Residue
B	PHE226
B	SER319
B	TYR334
B	ASN365
B	HOH2440
B	VAL96
B	GLU97
B	ASP98
B	PHE103
B	PHE105
B	TYR211
B	HIS213

site_id	AC5
Number of Residues	40
Details	BINDING SITE FOR RESIDUE NHW C 1000

Chain	Residue
C	TYR28
C	LYS29
C	PHE30
C	TRP31
C	ASN94
C	TYR95
C	VAL96
C	ASN161
C	PHE162
C	LEU163
C	CYS164
C	VAL165
C	ARG170
C	SER171
C	LYS172
C	ARG173
C	LEU174
C	ALA175
C	PRO176
C	THR183
C	ILE186
C	TRP192
C	GLN193
C	ALA194
C	TYR196
C	THR197
C	LEU202
C	TYR393
C	MG1413
C	HOH2001
C	HOH2002
C	HOH2269
C	HOH2275
C	HOH2276
C	HOH2501
C	HOH2502
C	HOH2503
C	HOH2504
C	HOH2505
C	HOH2506

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE U53 C 1001

Chain	Residue
C	VAL96
C	GLU97
C	ASP98
C	PHE103
C	PHE105
C	PHE226
C	SER319
C	LEU330
C	ALA332
C	TYR334
C	VAL363
C	ASN365
C	DMS1411
C	HOH2428
C	HOH2468

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS C 1411

Chain	Residue
C	TYR315
C	TYR334
C	LEU410
C	U531001
C	HOH2309
C	HOH2508

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 1411

Chain	Residue
A	GLU159
A	PHE281
A	TRP289
A	HOH2547

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS B 1411

Chain	Residue
B	GLU159
B	PHE281
B	TRP289
B	HOH2445

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS C 1412

Chain	Residue
C	GLU159
C	PHE281
C	TRP289
C	HOH2442

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1412

Chain	Residue
A	LEU169
A	SER171
A	LYS172
A	ARG173
A	LEU174
A	NHW1000

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1412

Chain	Residue
B	LEU169
B	SER171
B	LYS172
B	ARG173
B	LEU174
B	NHW1000

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 1413

Chain	Residue
C	LEU169
C	SER171
C	LYS172
C	ARG173
C	LEU174
C	NHW1000

site_id	BC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1413

Chain	Residue
A	ARG210
A	TYR212
A	LYS373
A	HOH2383
A	HOH2614
A	HOH2615
B	ARG210
B	TYR212
B	LYS373

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1414

Chain	Residue
A	ASN295
A	TYR298
A	SER316
A	ASN359
A	PHE361
A	HOH2538

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1415

Chain	Residue
A	LYS180
A	THR247
A	LEU248
A	ARG358
A	HOH2107

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1413

Chain	Residue
B	LYS180
B	THR247
B	LEU248
B	ARG358

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 1414

Chain	Residue
C	LYS180
C	THR247
C	LEU248
C	ARG358

Functional Information from PROSITE/UniProt

site_id	PS00975
Number of Residues	9
Details	NMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EVNFLCvHK

Chain	Residue	Details
A	GLU159-LYS167

site_id	PS00976
Number of Residues	7
Details	NMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGeGDG

Chain	Residue	Details
A	LYS380-GLY386

249697

PDB entries from 2026-02-25

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