5G1X

Crystal structure of Aurora-A kinase in complex with N-Myc

5G1X の概要

• エントリーDOI: 10.2210/pdb5g1x/pdb
• 分子名称: AURORA KINASE A, N-MYC PROTO-ONCOGENE PROTEIN, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: transferase, aurora, aurora-a, kinase, n-myc, myc, neuroblastoma
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965; Nucleus: P04198
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40618.23

構造登録者

Richards, M.W.,Burgess, S.G.,Bayliss, R. (登録日: 2016-03-31, 公開日: 2016-11-16, 最終更新日: 2024-01-10)

• 主引用文献: Richards, M.,Burgess, S.,Poon, E.,Carstensen, A.,Eilers, M.,Chesler, L.,Bayliss, R.; Structural Basis of N-Myc Binding by Aurora-A and its Destabilization by Kinase Inhibitors; Proc.Natl.Acad.Sci.USA, 113:13726-, 2016; PubMed: 27837025; DOI: 10.1073/PNAS.1610626113

実験手法

X-RAY DIFFRACTION (1.72 Å)