5G1O

Aspartate transcarbamoylase domain of human CAD in apo form

Summary for 5G1O

• Entry DOI: 10.2210/pdb5g1o/pdb
• Related: 5G1N 5G1P
• Descriptor: CAD protein, 1,2-ETHANEDIOL, GLYCEROL, ... (4 entities in total)
• Functional Keywords: transferase, de novo pyrimidine synthesis, transcarbamoylase, transcarbamylase, cad, carbamoyl phosphate synthetase, dihydroorotase, cooperativity
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P27708
• Total number of polymer chains: 6
• Total formula weight: 209963.06

Authors

Ruiz-Ramos, A.,Grande-Garcia, A.,Moreno-Morcillo, M.D.,Ramon-Maiques, S. (deposition date: 2016-03-29, release date: 2016-06-22, Last modification date: 2024-01-10)

• Primary citation: Ruiz-Ramos, A.,Velazquez-Campoy, A.,Grande-Garcia, A.,Moreno-Morcillo, M.,Ramon-Maiques, S.; Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala.; Structure, 24:1081-, 2016; PubMed: 27265852; DOI: 10.1016/J.STR.2016.05.001

Experimental method

X-RAY DIFFRACTION (2.1 Å)