5G1O

Aspartate transcarbamoylase domain of human CAD in apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0016597	molecular_function	amino acid binding
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0004070	molecular_function	aspartate carbamoyltransferase activity
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0016597	molecular_function	amino acid binding
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0004070	molecular_function	aspartate carbamoyltransferase activity
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0016597	molecular_function	amino acid binding
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0004070	molecular_function	aspartate carbamoyltransferase activity
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006520	biological_process	amino acid metabolic process
D	0016597	molecular_function	amino acid binding
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0004070	molecular_function	aspartate carbamoyltransferase activity
E	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
E	0006520	biological_process	amino acid metabolic process
E	0016597	molecular_function	amino acid binding
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0004070	molecular_function	aspartate carbamoyltransferase activity
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006520	biological_process	amino acid metabolic process
F	0016597	molecular_function	amino acid binding
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 3226

Chain	Residue
A	SER2015
A	ALA2018
A	ARG2040
C	ARG1986

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 3226

Chain	Residue
B	PRO2041
B	GLY1923
B	HIS1925
B	CYS2038
B	ARG2039
B	ARG2040

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO E 3226

Chain	Residue
E	ARG2024
E	ASP2047

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO F 3226

Chain	Residue
F	GLY1923
F	HIS1925
F	CYS2038
F	ARG2039

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO F 3227

Chain	Residue
F	GLU1971
F	PRO2026
F	GLY2046
F	ASP2047
F	GLY2050

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL E 3227

Chain	Residue
E	GLY1989

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL C 3226

Chain	Residue
C	GLY1989

---

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FyEvSTRT

Chain	Residue	Details
A	PHE1969-THR1976

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A786","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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