5G0N

Structure of rat neuronal nitric oxide synthase D597N mutant heme domain in complex with N1-(5-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL) PYRIDIN-3-YL)-N1,N2-DIMETHYLETHANE-1,2-DIAMINE

Summary for 5G0N

• Entry DOI: 10.2210/pdb5g0n/pdb
• Related: 5G0O 5G0P
• Descriptor: NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• Functional Keywords: oxidoreductase, nitric oxide synthase, inhibitor complex
• Biological source: RATTUS NORVEGICUS (NORWAY RAT)
• Cellular location: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• Total number of polymer chains: 2
• Total formula weight: 100120.88

Authors

Li, H.,Poulos, T.L. (deposition date: 2016-03-21, release date: 2016-06-15, Last modification date: 2016-07-27)

• Primary citation: Li, H.,Wang, H.,Kang, S.,Silverman, R.B.,Poulos, T.L.; Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase.; Biochemistry, 55:3702-, 2016; PubMed: 27250740; DOI: 10.1021/ACS.BIOCHEM.6B00261

Experimental method

X-RAY DIFFRACTION (1.936 Å)