5FWJ

Crystal structure of human JARID1C in complex with KDM5-C49

Summary for 5FWJ

• Entry DOI: 10.2210/pdb5fwj/pdb
• Descriptor: HISTONE DEMETHYLASE JARID1C, MAGNESIUM ION, ZINC ION, ... (6 entities in total)
• Functional Keywords: oxidoreductase, lysine-specific, lysine-specific demethylase 5c
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus : P41229
• Total number of polymer chains: 2
• Total formula weight: 109519.38

Authors

Srikannathasan, V.,Szykowska, A.,Strain-Damerell, C.,Kopec, J.,Nowak, R.,Gileadi, C.,Johansson, C.,Kupinska, K.,Burgess-Brown, N.A.,Shrestha, L.,Dong, W.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Huber, K.,Oppermann, U. (deposition date: 2016-02-17, release date: 2016-04-13, Last modification date: 2024-01-10)

• Primary citation: Johansson, C.,Velupillai, S.,Tumber, A.,Szykowska, A.,Hookway, E.S.,Nowak, R.P.,Strain-Damerell, C.,Gileadi, C.,Philpott, M.,Burgess-Brown, N.,Wu, N.,Kopec, J.,Nuzzi, A.,Steuber, H.,Egner, U.,Badock, V.,Munro, S.,Lathangue, N.B.,Westaway, S.,Brown, J.,Athanasou, N.,Prinjha, R.,Brennan, P.E.,Oppermann, U.; Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.; Nat.Chem.Biol., 12:539-, 2016; PubMed: 27214403; DOI: 10.1038/NCHEMBIO.2087

Experimental method

X-RAY DIFFRACTION (2.1 Å)