5FW5
Crystal structure of human G3BP1 in complex with Semliki Forest Virus nsP3-25 comprising two FGDF motives
Summary for 5FW5
Entry DOI | 10.2210/pdb5fw5/pdb |
Descriptor | RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 1, NON-STRUCTURAL PROTEIN 3, SULFATE ION, ... (7 entities in total) |
Functional Keywords | hydrolase, transferase, nonstructural protein 3 (nsp3), ras-gtpase activating protein sh3 domain binding protein g3bp1, rasputin, stress granule associated |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm: Q13283 Non-structural polyprotein: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side. P123: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side. mRNA-capping enzyme nsP1: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side. Protease nsP2: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side. RNA-directed RNA polymerase nsP4: Host endosome membrane; Peripheral membrane protein; Cytoplasmic side: P08411 |
Total number of polymer chains | 3 |
Total formula weight | 35656.03 |
Authors | Schulte, T.,Liu, L.,Panas, M.D.,Thaa, B.,Goette, B.,Achour, A.,McInerney, G.M. (deposition date: 2016-02-12, release date: 2016-07-20, Last modification date: 2024-01-10) |
Primary citation | Schulte, T.,Liu, L.,Panas, M.D.,Thaa, B.,Dickson, N.,Gotte, B.,Achour, A.,McInerney, G.M. Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication. Open Biol, 6:-, 2016 Cited by PubMed: 27383630DOI: 10.1098/rsob.160078 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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